PDB entry 4xh9

View 4xh9 on RCSB PDB site
Description: crystal structure of human rhoa in complex with dh/ph fragment of the guanine nucleotide exchange factor net1
Class: signaling protein
Keywords: rhoa gtpase, signaling protein, activator, guanine nucleotide exchange factor
Deposited on 2015-01-05, released 2015-01-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-01-14, with a file datestamp of 2015-01-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.19
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuroepithelial cell-transforming gene 1 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: NET1, ARHGEF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7Z628 (Start-354)
      • expression tag (355-360)
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (Start-179)
      • engineered mutation (24)
    Domains in SCOPe 2.07: d4xh9b_
  • Chain 'D':
    Compound: Neuroepithelial cell-transforming gene 1 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: NET1, ARHGEF8
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7Z628 (Start-354)
      • expression tag (355-360)
  • Chain 'E':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (Start-179)
      • engineered mutation (24)
    Domains in SCOPe 2.07: d4xh9e_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4xh9B (B:)
    gaairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdt
    agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
    lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xh9B (B:)
    airkklvivgdgacgktcllivnspevyvptvfenyvadievdgkqvelalwdtagqedy
    drlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndeh
    trrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
    

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4xh9E (E:)
    gaairkklvivgdgacgktcllivnskdqfpevyvptvfenyvadievdgkqvelalwdt
    agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
    lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xh9E (E:)
    airkklvivgdgacgktcllivnspevyvptvfenyvadievdgkqvelalwdtagqedy
    drlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndeh
    trrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq