PDB entry 4x8v

View 4x8v on RCSB PDB site
Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR (methyl {3-[(2R)-1-{(2R)-2-(3,4-dimethoxyphenyl)-2-[(1-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]acetyl}pyrrolidin-2-yl]-4-(propan-2-ylsulfonyl)phenyl}carbamate)
Class: hydrolase/hydrolase inhibitor
Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding
Deposited on 2014-12-10, released 2015-03-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-04-08, with a file datestamp of 2015-04-03.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'H':
  Compound: Factor VIIa (Heavy Chain)
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-253)
  Domains in SCOPe 2.07: d4x8vh_
• Chain 'L':
  Compound: Factor VIIa (Light Chain)
  Species: Homo sapiens [TaxId:9606]
  Gene: F7
  Database cross-references and differences (RAF-indexed):
  • Uniprot P08709 (0-54)
  Domains in SCOPe 2.07: d4x8vl_
• Heterogens: 3Z9, CA, SO4, GOL, HOH

PDB Chain Sequences:

• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4x8vH (H:)
  ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
  lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
  lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
  sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
  seprpgvllrapfp
  

  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4x8vL (L:)
  icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr