PDB entry 4x8t

View 4x8t on RCSB PDB site
Description: FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 7-chloro-3,4-dihydroisoquinolin-1(2H)-one
Class: hydrolase/hydrolase inhibitor
Keywords: GLYCOPROTEIN, HYDROLASE, SERINE PROTEASE, PLASMA, BLOOD COAGULATION FACTOR, PROTEIN INHIBITOR COMPLEX, CALCIUM- BINDING, hydrolase-hydrolase inhibitor complex
Deposited on 2014-12-10, released 2015-03-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-04-08, with a file datestamp of 2015-04-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Factor VIIa (Heavy Chain)
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x8th_
  • Chain 'L':
    Compound: Factor VIIa (Light Chain)
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4x8tl_
  • Heterogens: 3Z8, CA, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4x8tH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrkvgdspniteymfcagy
sdgskdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmr
seprpgvllrapfp

    Sequence, based on observed residues (ATOM records): (download) 
    >4x8tH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdclqqsrspniteymfcagysdgs
kdsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrsepr
pgvllrapfp

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4x8tL (L:)
icvnenggceqycsdhtgtkrscrchegyslladgvsctptveypcgkipilekr