PDB entry 4x8c

View 4x8c on RCSB PDB site
Description: Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with GSK147
Class: Hydrolase/Hydrolase Inhibitor
Keywords: Hydrolase-Hydrolase Inhibitor complex
Deposited on 2014-12-10, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein-arginine deiminase type-4
    Species: Homo sapiens [TaxId:9606]
    Gene: PADI4, PADI5, PDI5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM07 (Start-670)
      • engineered mutation (652)
    Domains in SCOPe 2.08: d4x8ca1, d4x8ca2
  • Heterogens: CA, 3YZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x8cA (A:)
gplgspefmaqgtlirvtpeqpthavcvlgtltqldicssapedctsfsinaspgvvvdi
ahgppakkkstgsstwpldpgvevtltmkvasgstgdqkvqisyygpktppvkallyltg
veislcaditrtgkvkptravkdqrtwtwgpcgqgaillvncdrdnlessamdceddevl
dsedlqdmslmtlstktpkdfftnhtlvlhvarsemdkvrvfqatrgklsskcsvvlgpk
wpshylmvpggkhnmdfyvealafpdtdfpglitltislldtsnlelpeavvfqdsvvfr
vapwimtpntqppqevyacsifenedflksvttlamkakcklticpeeenmddqwmqdem
eigyiqaphktlpvvfdsprnrglkefpikrvmgpdfgyvtrgpqtggisgldsfgnlev
sppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqqvqapvklysdwlsvghv
deflsfvpapdrkgfrlllasprscyklfqeqqneghgeallfegikkkkqqkiknilsn
ktlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskaeaffpnmvnmlvl
gkhlgipkpfgpvingrccleekvcslleplglqctfindfftyhirhgevhagtnvrrk
pfsfkwwnmvp

    Sequence, based on observed residues (ATOM records): (download) 
    >4x8cA (A:)
qgtlirvtpeqpthavcvlgtltqldicssactsfsinaspgvvvdiwplevtltmkvas
gstgdqkvqisyypvkallyltgveislcaditrtgkvkpkdqrtwtwgpcgqgaillvn
cdsedlqdmslmtlstktpkdfftnhtlvlhvarsemdkvrvfqatrgklsskcsvvlgp
kwpshylmvpggkhnmdfyvealafpdtdfpglitltislldtsnlelpeavvfqdsvvf
rvapwimtpntqppqevyacnedflksvttlamkakcklticdemeigyiqaphktlpvv
fdsfgysgldsfgnlevsppvtvrgkeyplgrilfgdscypsndsrqmhqalqdflsaqq
vqapvklysdwlsvghvdeflsfvpapdrkgfrlllasprscyklfqeqqneghgeallf
ekqqkiknilsnktlrehnsfvercidwnrellkrelglaesdiidipqlfklkefskae
affpnmvnmlvlgkhlgipkpfccleekvcslleplglqctfindfftyhigevhagtnv
rrkpfsfkwwnmvp