PDB entry 4x1f

View 4x1f on RCSB PDB site
Description: Crystal structure of the hPXR-LBD in complex with the synthetic estrogen 17alpha-ethinylestradiol
Class: gene regulation
Keywords: nuclear receptor, hormone receptor, pregnane X receptor, estrogen, gene regulation
Deposited on 2014-11-24, released 2015-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-07-04, with a file datestamp of 2018-06-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor subfamily 1 group I member 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NR1I2, PXR
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4x1fa_
  • Heterogens: 3WF, MPD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4x1fA (A:)
mkkghhhhhhgsertgtqplgvqglteeqrmmirelmdaqmktfdttfshfknfrlpgvl
ssgcelpeslqapsreeaakwsqvrkdlcslkvslqlrgedgsvwnykppadsggkeifs
llphmadmstymfkgiisfakvisyfrdlpiedqisllkgaafelcqlrfntvfnaetgt
wecgrlsycledtaggfqqlllepmlkfhymlkklqlheeeyvlmqaislfspdrpgvlq
hrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsinaqhtqrllriqdih
pfatplmqelfgitgs

    Sequence, based on observed residues (ATOM records): (download) 
    >4x1fA (A:)
glteeqrmmirelmdaqmktfdttfshfknfrlpgveaakwsqvrkdlcslkvslqlrge
dgsvwnykppadsggkeifsllphmadmstymfkgiisfakvisyfrdlpiedqisllkg
aafelcqlrfntvfnaetgtwecgrlsycledqqlllepmlkfhymlkklqlheeeyvlm
qaislfspdrpgvlqhrvvdqlqeqfaitlksyiecnrpqpahrflflkimamltelrsi
naqhtqrllriqdihpfatplmqelfgitgs