PDB entry 4wwo

View 4wwo on RCSB PDB site
Description: Crystal structure of human PI3K-gamma in complex with phenylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Class: transferase/transferase inhibitor
Keywords: kinase, phosphotransfer, PIP2, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-11-11, released 2014-12-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4wwoa1, d4wwoa2, d4wwoa3, d4wwoa4
  • Heterogens: SO4, 3VD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4wwoA (A:)
    seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
    skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
    sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeew
    plvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfv
    eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalss
    kasaespsseskgkvqllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadklt
    satnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdp
    lnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsald
    vgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllk
    rglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlq
    kvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckv
    maskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlc
    llpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqa
    averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkerv
    pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
    skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
    

    Sequence, based on observed residues (ATOM records): (download)
    >4wwoA (A:)
    sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
    lpeylwkkianncifivihrsttsqtikvspddtpgailqvlrvcgrdeylvgetpiknf
    qwvrhclkngeeihvvldtppdpaldevrkevslwdcdrkfrvkirgidipvlltvfvea
    niqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgvqllyyvnl
    llidhrfllrrgeyvlhmwqisgsfnadkltsatnpdkensmsisilldnaempnqlrkq
    leaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarr
    evwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhd
    salarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftq
    qvqviemlqkvtldikslsvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaie
    kckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetes
    ldlcllpygcistgdkigmieivkdattiakiqqstvgfkdevlnhwlkekspteekfqa
    averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghikervpfvltpdflfv
    mgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmptskedieyirdalt
    vgkneedakkyfldqievcrdkgwtvqfnwflhl