PDB entry 4wun

View 4wun on RCSB PDB site
Description: Structure of FGFR1 in complex with AZD4547 (N-{3-[2-(3,5-DIMETHOXYPHENYL)ETHYL]-1H-PYRAZOL-5-YL}-4-[(3R,5S)-3,5-DIMETHYLPIPERAZIN-1-YL]BENZAMIDE) at 1.65 angstrom
Class: transferase/transferase inhibitor
Keywords: transferase; transferase inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-11-02, released 2014-11-19
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-11-19, with a file datestamp of 2014-11-14.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.226
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-310)
      • conflict (33)
      • conflict (129)
    Domains in SCOPe 2.04: d4wuna_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • conflict (33)
    Domains in SCOPe 2.04: d4wunb_
  • Heterogens: 66T, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wunA (A:)
gamsgvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavk
mlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylq
arrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvted
nvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweif
tlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedl
drivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4wunA (A:)
lpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppleysy
npshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglp
vkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkps
nctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wunB (B:)
gamsgvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavk
mlksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylq
arrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvted
nvmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweif
tlggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedl
drivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4wunB (B:)
seyelpedprwelprdrlvlgkplgegafgqvvlaeaiglkpnrvtkvavkmlksdatek
dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppqlss
kdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgllpvkwmapealfd
riythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymmmr
dcwhavpsqrptfkqlvedldrivalts