PDB entry 4wlo

View 4wlo on RCSB PDB site
Description: Crystal structure of oxaloacetate and NADH bound MDH2
Class: oxidoreductase
Keywords: MDH2, TCA cycle, OXIDOREDUCTASE
Deposited on 2014-10-07, released 2015-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-11-25, with a file datestamp of 2015-11-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Malate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wloa1, d4wloa2
  • Chain 'B':
    Compound: Malate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wlob1, d4wlob2
  • Chain 'C':
    Compound: Malate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wloc1, d4wloc2
  • Chain 'D':
    Compound: Malate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: MDH2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4wlod1, d4wlod2
  • Heterogens: NAI, OAA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wloA (A:)
mgsshhhhhhssglvprgshmsaqnnakvavlgasggigqplslllknsplvsrltlydi
ahtpgvaadlshietkaavkgylgpeqlpdclkgcdvvvipagvprkpgmtrddlfntna
tivatltaacaqhcpeamicvianpvnstipitaevfkkhgvynpnkifgvttldivran
tfvaelkgldparvnvpvigghagktiiplisqctpkvdfpqdqltaltgriqeagtevv
kakagagsatlsmayagarfvfslvdamngkegvvecsfvksqetectyfstplllgkkg
ieknlgigkvssfeekmisdaipelkasikkgedfvktlk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wloA (A:)
nakvavlgasggigqplslllknsplvsrltlydiahtpgvaadlshietkaavkgylgp
eqlpdclkgcdvvvipagvprkpgmtrddlfntnativatltaacaqhcpeamicvianp
vnstipitaevfkkhgvynpnkifgvttldivrantfvaelkgldparvnvpvigghagk
tiiplisqctpkvdfpqdqltaltgriqeagtevvkakagagsatlsmayagarfvfslv
damngkegvvecsfvksqetectyfstplllgkkgieknlgigkvssfeekmisdaipel
kasikkgedfvktl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wloB (B:)
mgsshhhhhhssglvprgshmsaqnnakvavlgasggigqplslllknsplvsrltlydi
ahtpgvaadlshietkaavkgylgpeqlpdclkgcdvvvipagvprkpgmtrddlfntna
tivatltaacaqhcpeamicvianpvnstipitaevfkkhgvynpnkifgvttldivran
tfvaelkgldparvnvpvigghagktiiplisqctpkvdfpqdqltaltgriqeagtevv
kakagagsatlsmayagarfvfslvdamngkegvvecsfvksqetectyfstplllgkkg
ieknlgigkvssfeekmisdaipelkasikkgedfvktlk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wloB (B:)
nakvavlgasggigqplslllknsplvsrltlydiahtpgvaadlshietkaavkgylgp
eqlpdclkgcdvvvipagvprkpgmtrddlfntnativatltaacaqhcpeamicvianp
vnstipitaevfkkhgvynpnkifgvttldivrantfvaelkgldparvnvpvigghagk
tiiplisqctpkvdfpqdqltaltgriqeagtevvkakagagsatlsmayagarfvfslv
damngkegvvecsfvksqetectyfstplllgkkgieknlgigkvssfeekmisdaipel
kasikkgedfvktl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4wloC (C:)
mgsshhhhhhssglvprgshmsaqnnakvavlgasggigqplslllknsplvsrltlydi
ahtpgvaadlshietkaavkgylgpeqlpdclkgcdvvvipagvprkpgmtrddlfntna
tivatltaacaqhcpeamicvianpvnstipitaevfkkhgvynpnkifgvttldivran
tfvaelkgldparvnvpvigghagktiiplisqctpkvdfpqdqltaltgriqeagtevv
kakagagsatlsmayagarfvfslvdamngkegvvecsfvksqetectyfstplllgkkg
ieknlgigkvssfeekmisdaipelkasikkgedfvktlk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wloC (C:)
nakvavlgasggigqplslllknsplvsrltlydiahtpgvaadlshietkaavkgylgp
eqlpdclkgcdvvvipagvprkpgmtrddlfntnativatltaacaqhcpeamicvianp
vnstipitaevfkkhgvynpnkifgvttldivrantfvaelkgldparvnvpvigghagk
tiiplisqctpkvdfpqdqltaltgriqeagtevvkakagagsatlsmayagarfvfslv
damngkegvvecsfvksqetectyfstplllgkkgieknlgigkvssfeekmisdaipel
kasikkgedfvktl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wloD (D:)
mgsshhhhhhssglvprgshmsaqnnakvavlgasggigqplslllknsplvsrltlydi
ahtpgvaadlshietkaavkgylgpeqlpdclkgcdvvvipagvprkpgmtrddlfntna
tivatltaacaqhcpeamicvianpvnstipitaevfkkhgvynpnkifgvttldivran
tfvaelkgldparvnvpvigghagktiiplisqctpkvdfpqdqltaltgriqeagtevv
kakagagsatlsmayagarfvfslvdamngkegvvecsfvksqetectyfstplllgkkg
ieknlgigkvssfeekmisdaipelkasikkgedfvktlk

    Sequence, based on observed residues (ATOM records): (download) 
    >4wloD (D:)
nakvavlgasggigqplslllknsplvsrltlydiahtpgvaadlshietkaavkgylgp
eqlpdclkgcdvvvipagvprkpgmtrddlfntnativatltaacaqhcpeamicvianp
vnstipitaevfkkhgvynpnkifgvttldivrantfvaelkgldparvnvpvigghagk
tiiplisqctpkvdfpqdqltaltgriqeagtevvkakagagsatlsmayagarfvfslv
damngkegvvecsfvksqetectyfstplllgkkgieknlgigkvssfeekmisdaipel
kasikkgedfvktl