PDB entry 4wkp

View 4wkp on RCSB PDB site
Description: Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with 2-(2-hydroxyethoxy)ethylthiomethyl-DADMe-Immucillin-A
Class: hydrolase/hydrolase inhibitor
Keywords: hydrolase, hydrolase-hydrolase inhibitor complex
Deposited on 2014-10-02, released 2015-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.58 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aminodeoxyfutalosine nucleosidase
    Species: Helicobacter pylori [TaxId:85963]
    Gene: mtnN, mtn, jhp_0082
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9ZMY2 (16-244)
      • expression tag (15)
    Domains in SCOPe 2.08: d4wkpa1, d4wkpa2
  • Chain 'B':
    Compound: Aminodeoxyfutalosine nucleosidase
    Species: Helicobacter pylori [TaxId:85963]
    Gene: mtnN, mtn, jhp_0082
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9ZMY2 (16-244)
      • expression tag (15)
    Domains in SCOPe 2.08: d4wkpb1, d4wkpb2
  • Chain 'C':
    Compound: Aminodeoxyfutalosine nucleosidase
    Species: Helicobacter pylori [TaxId:85963]
    Gene: mtnN, mtn, jhp_0082
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9ZMY2 (16-244)
      • expression tag (15)
    Domains in SCOPe 2.08: d4wkpc1, d4wkpc2
  • Chain 'D':
    Compound: Aminodeoxyfutalosine nucleosidase
    Species: Helicobacter pylori [TaxId:85963]
    Gene: mtnN, mtn, jhp_0082
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9ZMY2 (16-244)
      • expression tag (15)
    Domains in SCOPe 2.08: d4wkpd1, d4wkpd2
  • Heterogens: 3QA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wkpA (A:)
mghhhhhhenlyfqgvqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkei
ivayskigkvhstltttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdls
afdhplgfipesaifietsgslnalakkianeqhialkegviasgdqfvhskerkeflvs
efkasavemegasvafvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflks
mvdel

    Sequence, based on observed residues (ATOM records): (download) 
    >4wkpA (A:)
vqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkeiivayskigkvhstlt
ttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdlsafdhplgfipesaif
ietsgslnalakkianeqhialkegviasgdqfvhskerkeflvsefkasavemegasva
fvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflksmvdel

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4wkpB (B:)
mghhhhhhenlyfqgvqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkei
ivayskigkvhstltttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdls
afdhplgfipesaifietsgslnalakkianeqhialkegviasgdqfvhskerkeflvs
efkasavemegasvafvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflks
mvdel

    Sequence, based on observed residues (ATOM records): (download) 
    >4wkpB (B:)
vqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkeiivayskigkvhstlt
ttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdlsafdhplgfipesaif
ietsgslnalakkianeqhialkegviasgdqfvhskerkeflvsefkasavemegasva
fvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflksmvdel

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4wkpC (C:)
mghhhhhhenlyfqgvqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkei
ivayskigkvhstltttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdls
afdhplgfipesaifietsgslnalakkianeqhialkegviasgdqfvhskerkeflvs
efkasavemegasvafvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflks
mvdel

    Sequence, based on observed residues (ATOM records): (download) 
    >4wkpC (C:)
vqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkeiivayskigkvhstlt
ttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdlsafdhplgfipesaif
ietsgslnalakkianeqhialkegviasgdqfvhskerkeflvsefkasavemegasva
fvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflksmvdel

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4wkpD (D:)
mghhhhhhenlyfqgvqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkei
ivayskigkvhstltttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdls
afdhplgfipesaifietsgslnalakkianeqhialkegviasgdqfvhskerkeflvs
efkasavemegasvafvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflks
mvdel

    Sequence, based on observed residues (ATOM records): (download) 
    >4wkpD (D:)
vqkigilgamreeitpilelfgvdfeeiplggnvfhkgvyhnkeiivayskigkvhstlt
ttsmilafgvqkvlfsgvagslvkdlkindllvatqlvqhdvdlsafdhplgfipesaif
ietsgslnalakkianeqhialkegviasgdqfvhskerkeflvsefkasavemegasva
fvcqkfgvpccvlrsisdnadekagmsfdefleksahtsakflksmvdel