PDB entry 4wk7
View 4wk7 on RCSB PDB site
Description: Crystal structure of human ADAMTS-4 in complex with inhibitor (compound 1, 2-(4-chlorophenoxy)-N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl} acetamide)
Class: hydrolase/hydrolase inhibitor
Keywords: Metalloprotease, Osteoarthritis, Inhibitor, hydrolase-hydrolase inhibitor complex
Deposited on
2014-10-01, released
2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-09-27, with a file datestamp of
2017-09-22.
Experiment type: XRAY
Resolution: 1.24 Å
R-factor: N/A
AEROSPACI score: 0.62
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: A disintegrin and metalloproteinase with thrombospondin motifs 4
Species: Homo sapiens [TaxId:9606]
Gene: ADAMTS4, KIAA0688, UNQ769/PRO1563
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4wk7a_ - Heterogens: ZN, CA, 3PQ, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4wk7A (A:)
faslsrfvetlvvaddkmaafhgaglkrylltvmaaaakafkhpsirnpvslvvtrlvil
gsgeegpqvgpsaaqtlrsfcawqrglntpedsdpdhfdtailftrqdlcgvstcdtlgm
advgtvcdparscaiveddglqsaftaahelghvfnmlhdnskpcislngplstsrhvma
pvmahvdpeepwspcsarfitdfldngyghclldkpeaplhlpvtfpdvhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4wk7A (A:)
srfvetlvvaddkmaafhgaglkrylltvmaaaakafkhpsirnpvslvvtrlvilgpqv
gpsaaqtlrsfcawqrglntpedsdpdhfdtailftrqdlcgvstcdtlgmadvgtvcdp
arscaiveddglqsaftaahelghvfnmlhdnskpcislngplsrhvmapvmahvdpeep
wspcsarfitdfldngyghclldkpeapl