PDB entry 4wjg

View 4wjg on RCSB PDB site
Description: Structure of T. brucei haptoglobin-hemoglobin receptor binding to human haptoglobin-hemoglobin
Class: endocytosis
Keywords: Endocytosis, Trypanosome, Receptor
Deposited on 2014-09-30, released 2014-11-26
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-11-26, with a file datestamp of 2014-11-21.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.255
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

• Chain '1':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
  Domains in SCOPe 2.04: d4wjg1_
• Chain '2':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain '3':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
  Domains in SCOPe 2.04: d4wjg3_
• Chain '4':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'A':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
• Chain 'B':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
  Domains in SCOPe 2.04: d4wjgb_
• Chain 'C':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain 'D':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
• Chain 'E':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'F':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
  Domains in SCOPe 2.04: d4wjgf_
• Chain 'G':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
• Chain 'H':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain 'I':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
• Chain 'J':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'K':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
• Chain 'L':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
• Chain 'M':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain 'N':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
• Chain 'O':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'P':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
• Chain 'Q':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
• Chain 'R':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain 'S':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
• Chain 'T':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'U':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
• Chain 'V':
  Compound: Hemoglobin subunit beta
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P68871 (0-145)
• Chain 'W':
  Compound: Haptoglobin
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P00738 (0-End)
• Chain 'X':
  Compound: Iron-regulated surface determinant protein H
  Species: Staphylococcus aureus [TaxId:158879]
  Gene: isdH, harA, sasI, SA1552
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q99TD3 (2-145)
• Chain 'Y':
  Compound: Haptoglobin-hemoglobin receptor
  Species: Trypanosoma brucei brucei [TaxId:5702]
  Gene: HpHbR
  Database cross-references and differences (RAF-indexed):
  • Uniprot I7BA80 (0-End)
• Chain 'Z':
  Compound: Hemoglobin subunit alpha
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P69905 (0-140)
• Heterogens: HEM, OXY, NAG

PDB Chain Sequences:

• Chain '1':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4wjg1 (1:)
  vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
  kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
  eftppvqaayqkvvagvanalahkyh
  

  
  
• Chain '2':
  No sequence available.
  
  
• Chain '3':
  Sequence, based on SEQRES records: (download)
  

  >4wjg3 (3:)
  gsadeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkk
  aeveldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstq
  iddgeetnydytklvfakpiyndpsl
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4wjg3 (3:)
  adeslkdaikdpalenkehdigpreqvnfqlldknnetqyyhffsikdpadvyytkkkae
  veldintastwkkfevyennqklpvrlvsyspvpedhayirfpvsdgtqelkivsstqid
  dgeetnydytklvfakpiyndpsl
  

  
  
• Chain '4':
  No sequence available.
  
  
• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4wjgB (B:)
  vhltpeeksavtalwgkvnvdevggealgrllvvypwtqrffesfgdlstpdavmgnpkv
  kahgkkvlgafsdglahldnlkgtfatlselhcdklhvdpenfrllgnvlvcvlahhfgk
  eftppvqaayqkvvagvanalahkyh
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'E':
  No sequence available.
  
  
• Chain 'F':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4wjgF (F:)
  vlspadktnvkaawgkvgahageygaealermflsfpttktyfphfdlshgsaqvkghgk
  kvadaltnavahvddmpnalsalsdlhahklrvdpvnfkllshcllvtlaahlpaeftpa
  vhasldkflasvstvltskyr
  

  
  
• Chain 'G':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'I':
  No sequence available.
  
  
• Chain 'J':
  No sequence available.
  
  
• Chain 'K':
  No sequence available.
  
  
• Chain 'L':
  No sequence available.
  
  
• Chain 'M':
  No sequence available.
  
  
• Chain 'N':
  No sequence available.
  
  
• Chain 'O':
  No sequence available.
  
  
• Chain 'P':
  No sequence available.
  
  
• Chain 'Q':
  No sequence available.
  
  
• Chain 'R':
  No sequence available.
  
  
• Chain 'S':
  No sequence available.
  
  
• Chain 'T':
  No sequence available.
  
  
• Chain 'U':
  No sequence available.
  
  
• Chain 'V':
  No sequence available.
  
  
• Chain 'W':
  No sequence available.
  
  
• Chain 'X':
  No sequence available.
  
  
• Chain 'Y':
  No sequence available.
  
  
• Chain 'Z':
  No sequence available.