PDB entry 4wf6

View 4wf6 on RCSB PDB site
Description: Anthrax toxin lethal factor with bound small molecule inhibitor MK-31
Class: hydrolase/hydrolase inhibitor
Keywords: Anthrax toxin, lethal factor, metalloproteinase, metalloprotease, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-09-12, released 2015-09-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: lef, pXO1-107, BXA0172, GBAA_pXO1_0172
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15917 (Start-514)
      • engineered mutation (4)
    Domains in SCOPe 2.07: d4wf6a1, d4wf6a2
  • Heterogens: ZN, 407, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4wf6A (A:)
snalsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkr
iqidssdflsteekeflkklqidirdslseeekellnriqvdssnplsekekeflkklkl
diqpydinqrlqdtgglidspsinldvrkqykrdiqnidallhqsigstlynkiylyenm
ninnltatlgadlvdstdntkinrgifnefkknfkysissnymivdinerpaldnerlkw
riqlspdtragylengklilqrnigleikdvqiikqsekeyiridakvvpkskidtkiqe
aqlninqewnkalglpkytklitfnvhnryasnivesaylilnewknniqsdlikkvtny
lvdgngrfvftditlpniaeqythqdeiyeqvhskglyvpesrsillhgpskgvelrnds
egfihefghavddyagylldknqsdlvtnskkfidifkeegsnltsygrtneaeffaeaf
rlmhstdhaerlkvqknapktfqfindqikfiinslvpr

    Sequence, based on observed residues (ATOM records): (download) 
    >4wf6A (A:)
sryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqid
ssdflsteekeflkklqidirdslseeekellnplsekekeflkklkldiqpydinqrlq
dtgglidspsinldvrkqykrdiqnidallhqsigstlynkiylyenmninnltatlgad
lvdstdntkinrgifnefkknfkysissnymivdinerpaldnerlkwriqlspdtragy
lengklilqrnigleikdvqiikqsekeyiridakvvpkskidtkiqeaqlninqewnka
lglpkytklitfnvhnryasnivesaylilnewknniqsdlikkvtnylvdgngrfvftd
itlpniaeqythqdeiyeqvhskglyvpesrsillhgpskgvelrndsegfihefghavd
dyagylldknqsdlvtnskkfidifkeegsnltsygrtneaeffaeafrlmhstdhaerl
kvqknapktfqfindqikfiins