PDB entry 4v04

View 4v04 on RCSB PDB site
Description: FGFR1 in complex with ponatinib.
Class: transferase
Keywords: transferase
Deposited on 2014-09-10, released 2014-12-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: 0.1881
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot D3DSX2 (Start-308)
      • engineered mutation (127)
    Domains in SCOPe 2.07: d4v04a_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed):
    • Uniprot D3DSX2 (1-308)
      • engineered mutation (31)
    Domains in SCOPe 2.07: d4v04b_
  • Heterogens: EDO, 0LI, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4v04A (A:)
    gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
    ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
    rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
    mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
    ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
    ivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4v04A (A:)
    yelpedprwelprdrlvlgkplgegqvvlaeaigldkdkpnrvtkvavkmlksdatekdl
    sdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleysn
    pshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglid
    yykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkl
    lkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4v04B (B:)
    gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
    ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
    rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
    mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
    ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
    ivaltsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4v04B (B:)
    agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
    sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
    ppeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglidyykk
    ttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeg
    hrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe