PDB entry 4v01

View 4v01 on RCSB PDB site
Description: FGFR1 in complex with ponatinib (co-crystallisation).
Class: transferase
Keywords: transferase
Deposited on 2014-09-10, released 2014-12-10
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-12-10, with a file datestamp of 2014-12-05.
Experiment type: XRAY
Resolution: 2.33 Å
R-factor: 0.1912
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4v01a_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, pfeiffer syndrome), isoform cra_b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4v01b_
  • Heterogens: SO4, EDO, 0LI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4v01A (A:)
gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
ivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4v01A (A:)
lpedprwelprdrlvlgkplggqvvlaeaigldkpnrvtkvavkmlksdatekdlsdlis
ememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppqlsskdlvsca
yqvargmeylaskkcihrdlaarnvlvtednvmkiadfidyykkttngrlpvkwmapeal
fdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctnelymm
mrdcwhavpsqrptfkqlvedldrivaltsnqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4v01B (B:)
gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
ivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4v01B (B:)
seyelpedprwelprdrlvlgkplgeggqvvlaeaigldpnrvtkvavkmlksdatekdl
sdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrpqlsskdl
vscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfidyykkttngrlpvkwma
pealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkpsnctne
lymmmrdcwhavpsqrptfkqlvedldrivaltsn