PDB entry 4uyg

View 4uyg on RCSB PDB site
Description: C-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)
Class: transcription
Keywords: transcription, inhibitor, histone, epigenetic reader, bet, brd2
Deposited on 2014-08-31, released 2014-10-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.19249
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uyga_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uygb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uygc_
  • Chain 'D':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uygd_
  • Chain 'E':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uyge_
  • Chain 'F':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4uygf_
  • Heterogens: 73B, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4uygA (A:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygA (A:)
    seqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmenr
    dyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4uygB (B:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygB (B:)
    seqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmenr
    dyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4uygC (C:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygC (C:)
    gklseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkm
    enrdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4uygD (D:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygD (D:)
    eqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmenrd
    yrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4uygE (E:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygE (E:)
    seqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmenr
    dyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4uygF (F:)
    mgsshhhhhhssglvprgshmhqsskkgklseqlkhcngilkellskkhaayawpfykpv
    dasalglhdyhdiikhpmdlstvkrkmenrdyrdaqefaadvrlmfsncykynppdhdvv
    amarklqdvfefryakmpdeplepgplpvstamppgl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4uygF (F:)
    lseqlkhcngilkellskkhaayawpfykpvdasalglhdyhdiikhpmdlstvkrkmen
    rdyrdaqefaadvrlmfsncykynppdhdvvamarklqdvfefryakmpd