PDB entry 4uwz

View 4uwz on RCSB PDB site
Description: Native FGFR1 with an inhibitor
Class: transferase
Keywords: transferase, fgfr1, drug, cancer, fgf, receptors, growth factors, signalling, enzyme
Deposited on 2014-08-15, released 2015-02-25
Made obsolete by 5am6 on 2015-03-18

The last revision prior to the SCOPe 2.05 freeze date was dated 2015-02-25, with a file datestamp of 2015-02-20.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: 0.2155
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (2-309)
      • expression tag (1)
    Domains in SCOPe 2.05: d4uwza_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • conflict (32)
    Domains in SCOPe 2.05: d4uwzb_
  • Heterogens: DOV, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uwzA (A:)
mvagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkm
lksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqa
rrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtedn
vmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweift
lggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedld
rivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4uwzA (A:)
vagvseyelpedprwelprdrlvlgkplgegqvvlaeaigldkdkpnrvtkvavkmlksd
atekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrpp
geeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihh
idyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelf
kllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4uwzB (B:)
mvagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkm
lksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqa
rrppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtedn
vmkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweift
lggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedld
rivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4uwzB (B:)
gvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlks
datekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrp
peeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglargrlp
vkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrmdkps
nctnelymmmrdcwhavpsqrptfkqlvedldrivalts