PDB entry 4uwc

View 4uwc on RCSB PDB site
Description: Fibroblast growth factor receptor 1 kinase in complex with JK-P3
Class: transferase
Keywords: transferase, receptor tyrosine kinase, transferase inhibitor
Deposited on 2014-08-11, released 2015-09-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-09-02, with a file datestamp of 2015-08-28.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-308)
      • engineered mutation (31)
      • engineered mutation (127)
    Domains in SCOPe 2.06: d4uwca_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (31)
      • engineered mutation (127)
    Domains in SCOPe 2.06: d4uwcb_
  • Heterogens: EDO, 4Y0, PPI, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4uwcA (A:)
gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
ivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4uwcA (A:)
lpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatekd
lsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppgleys
ynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfgl
ardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgv
pveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnq
e

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4uwcB (B:)
gagvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkml
ksdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqar
rppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednv
mkiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftl
ggspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldr
ivaltsnqe

    Sequence, based on observed residues (ATOM records): (download) 
    >4uwcB (B:)
gvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkpnrvtkvavkmlksda
tekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppg
leysyhnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfg
lardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypg
vpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsn
q