PDB entry 4tqc
View 4tqc on RCSB PDB site
Description: The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Class: protein binding
Keywords: eIF4E, translation initiation inhibitor, allosteric, 4EGI1, PROTEIN BINDING
Deposited on
2014-06-10, released
2014-08-13
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-08-23, with a file datestamp of
2017-08-18.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: eukaryotic translation initiation factor 4e
Species: Homo sapiens [TaxId:9606]
Gene: EIF4E, EIF4EL1, EIF4F
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4tqca_ - Chain 'B':
Compound: eukaryotic translation initiation factor 4e
Species: Homo sapiens [TaxId:9606]
Gene: EIF4E, EIF4EL1, EIF4F
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4tqcb_ - Heterogens: M7G, 34J, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4tqcA (A:)
mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
sgsttknrfvv
Sequence, based on observed residues (ATOM records): (download)
>4tqcA (A:)
ikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlsmpgcdyslfkdg
iepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcgavvnvr
akgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksknrfvv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4tqcB (B:)
mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
sgsttknrfvv
Sequence, based on observed residues (ATOM records): (download)
>4tqcB (B:)
ikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgcdyslf
kdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcgavv
nvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksknrfvv