PDB entry 4tqc

View 4tqc on RCSB PDB site
Description: The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Class: protein binding
Keywords: eIF4E, translation initiation inhibitor, allosteric, 4EGI1, PROTEIN BINDING
Deposited on 2014-06-10, released 2014-08-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-08-23, with a file datestamp of 2017-08-18.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: eukaryotic translation initiation factor 4e
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E, EIF4EL1, EIF4F
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4tqca_
  • Chain 'B':
    Compound: eukaryotic translation initiation factor 4e
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E, EIF4EL1, EIF4F
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4tqcb_
  • Heterogens: M7G, 34J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4tqcA (A:)
    mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
    pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
    ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
    sgsttknrfvv
    

    Sequence, based on observed residues (ATOM records): (download)
    >4tqcA (A:)
    ikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlsmpgcdyslfkdg
    iepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcgavvnvr
    akgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksknrfvv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4tqcB (B:)
    mvanpehyikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlm
    pgcdyslfkdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddys
    ddvcgavvnvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatk
    sgsttknrfvv
    

    Sequence, based on observed residues (ATOM records): (download)
    >4tqcB (B:)
    ikhplqnrwalwffkndksktwqanlrliskfdtvedfwalynhiqlssnlmpgcdyslf
    kdgiepmwedeknkrggrwlitlnkqqrrsdldrfwletllcligesfddysddvcgavv
    nvrakgdkiaiwttecenreavthigrvykerlglppkivigyqshadtatksknrfvv