PDB entry 4ryd

View 4ryd on RCSB PDB site
Description: X-ray structure of human furin in complex with the competitive inhibitor para-guanidinomethyl-Phac-R-Tle-R-Amba
Class: Hydrolase/Hydrolase Inhibitor
Keywords: competitive inhibitor, pro-protein convertase, serine protease, Hydrolase-Hydrolase Inhibitor complex
Deposited on 2014-12-15, released 2015-05-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-07-15, with a file datestamp of 2015-07-10.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ryda1, d4ryda2
  • Chain 'B':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4rydb1, d4rydb2
  • Chain 'C':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4rydc1, d4rydc2
  • Chain 'D':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4rydd1, d4rydd2
  • Chain 'E':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ryde1, d4ryde2
  • Chain 'F':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FUR, FURIN, PACE, PCSK3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4rydf1, d4rydf2
  • Chain 'H':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Chain 'I':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Chain 'J':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Chain 'K':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Chain 'L':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Chain 'N':
    Compound: para-guanidinomethyl-phenylacetyl-Arg-(3-methylvaline)-Arg-(amidomethyl)benzamidine
    Database cross-references and differences (RAF-indexed):
    • PDB 4RYD (0-4)
  • Heterogens: FMT, CA, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rydA (A:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydA (A:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rydB (B:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydB (B:)
yqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnan
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevrk
tvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgfn
dwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4rydC (C:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydC (C:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4rydD (D:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydD (D:)
yqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnan
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevrk
tvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgfn
dwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4rydE (E:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydE (E:)
yqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnan
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevrk
tvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgfn
dwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4rydF (F:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rydF (F:)
yqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnan
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevrk
tvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgfn
dwafmtthswdedpsgewvleientseannygtltkftlvlygta

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'N':
    No sequence available.