PDB entry 4rx8

View 4rx8 on RCSB PDB site
Description: SYK Catalytic Domain Complexed with a Potent Triazine Inhibitor2
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-12-09, released 2015-03-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-03-18, with a file datestamp of 2015-03-13.
Experiment type: XRAY
Resolution: 1.59 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase SYK
    Species: Homo sapiens [TaxId:9606]
    Gene: SYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P43405 (Start-282)
      • conflict (114)
      • expression tag (283-285)
    Domains in SCOPe 2.06: d4rx8a1, d4rx8a2
  • Heterogens: GOL, 3YX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rx8A (A:)
maleeirpkevyldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkneandpa
lkdellaeanvmqqldnpyivrmigiceaeswmlvmemaelgplnkylqqnrhvtdknii
elvhqvsmgmkyleesnfvhrdlaarnvllvtqhyakisdfglskalradenyykaqthg
kwpvkwyapecinyykfssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermg
cpagcpremydlmnlcwtydvenrpgfaavelrlrnyyydvvnhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rx8A (A:)
yldrklltledkelgsgnfgtvkkgyyqmkkvvktvavkilkpalkdellaeanvmqqld
npyivrmigiceaeswmlvmemaelgplnkylqqnrhvtdkniielvhqvsmgmkylees
nfvhrdlaarnvllvtqhyakisdfglskalradenyykaqtgkwpvkwyapecinyykf
ssksdvwsfgvlmweafsygqkpyrgmkgsevtamlekgermgcpagcpremydlmnlcw
tydvenrpgfaavelrlrnyyydvvnhhh