PDB entry 4rn1

View 4rn1 on RCSB PDB site
Description: Crystal structure of S39D HDAC8 in complex with a largazole analogue.
Class: hydrolase/hydrolase inhibitor
Keywords: metalloenzyme, hydrolase, histone deacetylase, enzyme inhibitor complex, largazole analogue, thiol inhibitor, arginase/deacetylase fold, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-10-22, released 2015-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-04-22, with a file datestamp of 2015-04-17.
Experiment type: XRAY
Resolution: 2.18 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (38)
      • expression tag (377)
    Domains in SCOPe 2.08: d4rn1a1, d4rn1a2
  • Chain 'B':
    Compound: Histone deacetylase 8
    Species: Homo sapiens [TaxId:9606]
    Gene: HDAC8, HDACL1, CDA07
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BY41 (Start-376)
      • engineered mutation (38)
    Domains in SCOPe 2.08: d4rn1b_
  • Heterogens: ZN, K, L8G, IMD, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rn1A (A:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rn1A (A:)
lvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfhtd
aylqhlqkvsqegddsieyglgydcpategifdyaaaiggatitaaqclidgmckvainw
sggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmt
vslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnp
kavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwty
ltgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv
i

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rn1B (B:)
meepeepadsgqslvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpk
vasmeematfhtdaylqhlqkvsqegdddhpdsieyglgydcpategifdyaaaiggati
taaqclidgmckvainwsggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlh
hgdgvedafsftskvmtvslhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdeky
yqicesvlkevyqafnpkavvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatli
lggggynlantarcwtyltgvilgktlsseipdhefftaygpdyvleitpscrpdrneph
riqqilnyikgnlkhvviegrgshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rn1B (B:)
slvpvyiyspeyvsmcdslakipkradmvhslieayalhkqmrivkpkvasmeematfht
daylqhlqkvsqdhpdsieyglgcpategifdyaaaiggatitaaqclidgmckvainws
ggwhhakkdeasgfcylndavlgilrlrrkferilyvdldlhhgdgvedafsftskvmtv
slhkfspgffpgtgdvsdvglgkgryysvnvpiqdgiqdekyyqicesvlkevyqafnpk
avvlqlgadtiagdpmcsfnmtpvgigkclkyilqwqlatlilggggynlantarcwtyl
tgvilgktlsseipdhefftaygpdyvleitpscrpdrnephriqqilnyikgnlkhvv