PDB entry 4rj7

View 4rj7 on RCSB PDB site
Description: EGFR kinase (T790M/L858R) with inhibitor compound 1
Class: Transferase/Transferase inhibitor
Keywords: protein kinase, phosphotransfer catalyst, Transferase-Transferase inhibitor complex
Deposited on 2014-10-08, released 2014-11-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-01-14, with a file datestamp of 2015-01-09.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.207
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (96)
      • engineered mutation (164)
    Domains in SCOPe 2.08: d4rj7a_
  • Heterogens: SO4, 3R1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rj7A (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqgns

    Sequence, based on observed residues (ATOM records): (download) 
    >4rj7A (A:)
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikespkankeild
eayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfgraklvpikwmalesilhriythqs
dvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmida
dsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfdmddvvdadeyli