PDB entry 4ra3

View 4ra3 on RCSB PDB site
Description: Crystal structure of dimeric S33C beta-2 microglobulin mutant in complex with Thioflavin (ThT) at 2.8 Angstrom resolution
Class: immune system
Keywords: amyloidosis, protein aggregation, thioflavin, covalent dimer, oligomerization, beta sandwich, inclusion bodies, IMMUNE SYSTEM
Deposited on 2014-09-09, released 2015-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-07, with a file datestamp of 2018-03-02.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P, NM_004048
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • expression tag (0)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d4ra3a1, d4ra3a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P, NM_004048
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-End)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d4ra3b_
  • Chain 'C':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P, NM_004048
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d4ra3c_
  • Chain 'D':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P, NM_004048
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • engineered mutation (33)
    Domains in SCOPe 2.08: d4ra3d_
  • Heterogens: TFX

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4ra3A (A:)
miqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ra3B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4ra3B (B:)
iqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ra3C (C:)
miqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4ra3C (C:)
iqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ra3D (D:)
miqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

    Sequence, based on observed residues (ATOM records): (download) 
    >4ra3D (D:)
iqrtpkiqvysrhpaengksnflncyvsgfhpcdievdllkngeriekvehsdlsfskdw
sfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm