PDB entry 4qyy

View 4qyy on RCSB PDB site
Description: Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State
Class: transferase/transferase inhibitor
Keywords: TRANSFERASE, SERINE/THREONINE-PROTEIN KINASE, MAP KINASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-07-26, released 2014-11-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.229
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Mapk1, Erk2, Mapk, Prkm1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4qyya_
  • Heterogens: 3G7, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qyyA (A:)
ahhhhhhmaaaaaagpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikk
ispfehqtycqrtlreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykl
lktqhlsndhicyflyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvad
pdhdhtgflteyvatrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyld
qlnhilgilgspsqedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmlt
fnphkrieveqalahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfq
pgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4qyyA (A:)
rgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrtlreiki
llrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqil
rglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatrwyr
apeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnc
iinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyle
qyydpsdepiaeapfklddlpkeklkelifeetarfq