PDB entry 4qge

View 4qge on RCSB PDB site
Description: phosphodiesterase-9A in complex with inhibitor WYQ-C36D
Class: hydrolase/hydrolase inhibitor
Keywords: PDE9 catalytic domain, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-05-22, released 2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-01-14, with a file datestamp of 2015-01-09.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.241
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphodiesterase 9A
    Species: Pan troglodytes [TaxId:9598]
    Gene: PDE9A
    Database cross-references and differences (RAF-indexed):
    • Uniprot K7AGW3
      • conflict (275)
      • conflict (279)
    Domains in SCOPe 2.08: d4qgea_
  • Chain 'B':
    Compound: Phosphodiesterase 9A
    Species: Pan troglodytes [TaxId:9598]
    Gene: PDE9A
    Database cross-references and differences (RAF-indexed):
    • Uniprot K7AGW3
      • conflict (275)
      • conflict (279)
    Domains in SCOPe 2.08: d4qgeb_
  • Heterogens: 35O, ZN, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4qgeA (A:)
mgsgsssyrpkaiyldidgriqkvifskycnssdimdlfciatglprnttisllttddam
vsidptmpansertpykvrpvaikqlsereeliqsvlaqvaeqfsrafkinelkaevanh
lavlekrveleglkvveiekcksdikkmreelaarssrtncpckysfldnhkkltprrdv
ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
qplwesrdryeelkriddamkelqkktdsltsgateksrersrdvknsegdca

    Sequence, based on observed residues (ATOM records): (download) 
    >4qgeA (A:)
kyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhd
nyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyq
inartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatd
marhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleey
fmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplw
esrdryeelkriddamkelqkk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4qgeB (B:)
mgsgsssyrpkaiyldidgriqkvifskycnssdimdlfciatglprnttisllttddam
vsidptmpansertpykvrpvaikqlsereeliqsvlaqvaeqfsrafkinelkaevanh
lavlekrveleglkvveiekcksdikkmreelaarssrtncpckysfldnhkkltprrdv
ptypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlf
cvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgyn
ntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitli
latdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdcl
leeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeiml
qplwesrdryeelkriddamkelqkktdsltsgateksrersrdvknsegdca

    Sequence, based on observed residues (ATOM records): (download) 
    >4qgeB (B:)
kyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrrwlfcvhd
nyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhpgynntyq
inartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmitlilatd
marhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwvdclleey
fmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmveeimlqplw
esrdryeelkriddamkelq