PDB entry 4q6a

View 4q6a on RCSB PDB site
Description: Staphylococcus aureus V31L, F98Y Mutant Dihydrofolate Reductase Complexed with NADPH
Class: oxidoreductase
Keywords: Oxidoreductase
Deposited on 2014-04-21, released 2014-12-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-18, with a file datestamp of 2015-02-13.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.167
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Staphylococcus aureus MUF168 [TaxId:1435480]
    Gene: dfrB, Y000_11620
    Database cross-references and differences (RAF-indexed):
    • Uniprot W7NDF6 (Start-157)
      • engineered mutation (31)
    Domains in SCOPe 2.08: d4q6aa_
  • Heterogens: NAP, GOL, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q6aA (A:)
mtlsilvahdlqrvigfenqlpwhlpndlkhlkklstghtlvmgrktfesigkplpnrrn
vvltsdtsfnvegvdvihsiediyqlpghvfifggqtlyeemidkvddmyitviegkfrg
dtffppytfedwevassvegkldekntiphtflhlirkle

    Sequence, based on observed residues (ATOM records): (download) 
    >4q6aA (A:)
tlsilvahdlqrvigfenqlpwhlpndlkhlkklstghtlvmgrktfesigkplpnrrnv
vltsdtsfnvegvdvihsiediyqlpghvfifggqtlyeemidkvddmyitviegkfrgd
tffppytfedwevassvegkldekntiphtflhlirk