PDB entry 4q0l

View 4q0l on RCSB PDB site
Description: Crystal structure of catalytic domain of human carbonic anhydrase isozyme XII with inhibitor
Class: lyase/lyase inhibitor
Keywords: drug design, carbonic anhydrase, benzenesulfonamide,metal-binding, lyase-lyase inhibitor comple, LYASE-LYASE INHIBITOR complex
Deposited on 2014-04-02, released 2015-01-28
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-01-28, with a file datestamp of 2015-01-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.27
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4q0la_
  • Chain 'B':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4q0lb_
  • Chain 'C':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4q0lc_
  • Chain 'D':
    Compound: Carbonic anhydrase 12
    Species: Homo sapiens [TaxId:9606]
    Gene: CA12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4q0ld_
  • Heterogens: ZN, V14, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4q0lA (A:)
mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
eminnfrqvqkfderlvytsfsq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q0lA (A:)
kwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfllt
nnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhyn
sdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnieel
lpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpsprem
innfrqvqkfderlvytsfsq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4q0lB (B:)
mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
eminnfrqvqkfderlvytsfsq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q0lB (B:)
kwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfllt
nnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhyn
sdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnieel
lpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpsprem
innfrqvqkfderlvytsfs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4q0lC (C:)
mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
eminnfrqvqkfderlvytsfsq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q0lC (C:)
kwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfllt
nnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhyn
sdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnieel
lpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpsprem
innfrqvqkfderlvytsfsq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4q0lD (D:)
mskwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfl
ltnnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivh
ynsdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnie
ellpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpspr
eminnfrqvqkfderlvytsfsq

    Sequence, based on observed residues (ATOM records): (download) 
    >4q0lD (D:)
kwtyfgpdgenswskkypscggllqspidlhsdilqydasltplefqgynlsankqfllt
nnghsvklnlpsdmhiqglqsrysatqlhlhwgnpndphgsehtvsgqhfaaelhivhyn
sdlypdastasnkseglavlavliemgsfnpsydkifshlqhvkykgqeafvpgfnieel
lpertaeyyryrgslttppcnptvlwtvfrnpvqisqeqllaletalycthmddpsprem
innfrqvqkfderlvytsfs