PDB entry 4pqn

View 4pqn on RCSB PDB site
Description: ITK kinase domain with compound GNE-9822
Class: transferase/transferase inhibitor
Keywords: protein kinase, phospho-transfer, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2014-03-03, released 2014-07-02
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-07-23, with a file datestamp of 2014-07-18.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: 0.161
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase ITK/TSK
    Species: Homo sapiens [TaxId:9606]
    Gene: ITK, EMT, LYK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08881 (2-End)
      • engineered mutation (122)
      • engineered mutation (259)
    Domains in SCOPe 2.04: d4pqna_
  • Heterogens: 2W6, P4G, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4pqnA (A:)
gsvidpseltfvqeigsgqfglvhlgywlnkdkvaiktiregamseedfieeaevmmkls
hpklvqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayle
easvihrdlaarnclvgenqvikvsdfgmtrfvlddqytsstgtkfpvkwaspevfsfsr
yssksdvwsfgvlmwevfsegkipyenrsnsevvedistgfrlykprlasthvyqimnhc
wkerpedrpafsrllrqlaaiaasgl

    Sequence, based on observed residues (ATOM records): (download) 
    >4pqnA (A:)
vidpseltfvqeigsgglvhlgywlnkdkvaiktiregamseedfieeaevmmklshpkl
vqlygvcleqapiclvfefmehgclsdylrtqrglfaaetllgmcldvcegmayleeasv
ihrdlaarnclvgenqvikvsdfgfpvkwaspevfsfsryssksdvwsfgvlmwevfseg
kipyenrsnsevvedistgfrlykprlasthvyqimnhcwkerpedrpafsrllrqlaai