PDB entry 4pj5

View 4pj5 on RCSB PDB site
Description: Structure of human MR1-Ac-6-FP in complex with human MAIT TRBV6-1 TCR
Class: immune system
Keywords: MR1, MAIT TCR, Ac-6-FP, Immune complex, IMMUNE SYSTEM
Deposited on 2014-05-12, released 2014-07-02
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.182
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4pj5a1, d4pj5a2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d4pj5b1, d4pj5b2
  • Chain 'C':
    Compound: Major histocompatibility complex class I-related gene protein
    Species: Homo sapiens [TaxId:9606]
    Gene: MR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q95460 (1-End)
      • engineered mutation (261)
    Domains in SCOPe 2.06: d4pj5c1, d4pj5c2
  • Chain 'D':
    Compound: TCR-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PJ5 (0-End)
    Domains in SCOPe 2.06: d4pj5d1, d4pj5d2
  • Chain 'E':
    Compound: TCR-beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PJ5
    Domains in SCOPe 2.06: d4pj5e1, d4pj5e2
  • Chain 'F':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4pj5f_
  • Chain 'G':
    Compound: TCR-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PJ5 (0-End)
    Domains in SCOPe 2.06: d4pj5g1, d4pj5g2
  • Chain 'H':
    Compound: TCR-beta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4PJ5
    Domains in SCOPe 2.06: d4pj5h1, d4pj5h2
  • Heterogens: 30W, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4pj5A (A:)
    mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
    erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
    lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
    epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
    awasieldpqssnlyschvehsgvhmvlqvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5A (A:)
    rthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhwe
    rytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdfl
    ifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrte
    pplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyqa
    wasiellyschvehsgvhmvlqv
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4pj5B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5B (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4pj5C (C:)
    mrthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhw
    erytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdf
    lifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrt
    epplvrvnrketfpgvtalfckahgfyppeiymtwmkngeeivqeidygdilpsgdgtyq
    awasieldpqssnlyschvehsgvhmvlqvp
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5C (C:)
    rthslryfrlgvsdpihgvpefisvgyvdshpittydsvtrqkeprapwmaenlapdhwe
    rytqllrgwqqmfkvelkrlqrhynhsgshtyqrmigcelledgsttgflqyaydgqdfl
    ifnkdtlswlavdnvahtikqaweanqhellyqknwleeeciawlkrfleygkdtlqrte
    pplvrvnrkalfckahgfyppeiymtwmkngeeidygdilpsgdgtyqawasieldpqss
    nlyschvehsgvhmvlqv
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4pj5D (D:)
    gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
    ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
    lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
    acanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5D (D:)
    gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
    ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
    lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
    acanafnnsiipedtffpsp
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4pj5E (E:)
    nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
    pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5E (E:)
    agvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevp
    ngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknv
    fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeq
    palndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
    gra
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4pj5F (F:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5F (F:)
    iqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskdw
    sfyllyyteftptekdeyacrvnhvtlsqpkivkwdr
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >4pj5G (G:)
    gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
    ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
    lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
    acanafnnsiipedtffpspess
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5G (G:)
    gqnidqptemtategaivqinctyqtsgfnglfwyqqhageaptflsynvldgleekgrf
    ssflsrskgysylllkelqmkdsasylcavkdsnyqliwgagtkliikpdiqnpdpavyq
    lrdsvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsdfacanafnns
    iipedtffps
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >4pj5H (H:)
    nagvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgev
    pngynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlkn
    vfppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplke
    qpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaea
    wgrad
    

    Sequence, based on observed residues (ATOM records): (download)
    >4pj5H (H:)
    gvtqtpkfqvlktgqsmtlqcaqdmnhnsmywyrqdpgmglrliyysasegttdkgevpn
    gynvsrlnkrefslrlesaapsqtsvyfcassvwtgegsgelffgegsrltvledlknvf
    ppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqp
    alndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
    ra