PDB entry 4p9h
View 4p9h on RCSB PDB site
Description: Crystal structure of 8ANC195 Fab in complex with gp120 of 93TH057 HIV-1 and soluble CD4 D1D2
Class: viral protein/immune system
Keywords: IG FOLD, ANTI HIV, ANTIBODY, IMMUNE SYSTEM COMPLEX, VIRAL PROTEIN-IMMUNE SYSTEM complex
Deposited on
2014-04-04, released
2014-05-21
The last revision prior to the SCOPe 2.06 freeze date was dated
2014-05-21, with a file datestamp of
2014-05-16.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.237
AEROSPACI score: 0.15
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'C':
Compound: T-cell surface glycoprotein cd4
Species: Homo sapiens [TaxId:9606]
Gene: CD4
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4p9hc1, d4p9hc2 - Chain 'G':
Compound: envelope glycoprotein gp120
Species: Human immunodeficiency virus 1 [TaxId:11676]
Gene: ENV
Database cross-references and differences (RAF-indexed):
- Uniprot Q0ED31 (0-79)
- engineered mutation (21)
- engineered mutation (44)
- engineered mutation (71)
- linker (80-81)
- Uniprot Q0ED31 (82-184)
- engineered mutation (172)
- Uniprot Q0ED31
- engineered mutation (201)
- engineered mutation (258)
- engineered mutation (308)
- Chain 'H':
Compound: Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4p9hl1, d4p9hl2 - Heterogens: EPE, BAM, NAG
PDB Chain Sequences:
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4p9hC (C:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknltiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
kaidgrhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4p9hC (C:)
kvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrsl
wdqgnfpliiknltiedsdtyicevedqkeevqllvfgltansdqsltltlesppgssps
vqcrsprgkniqggktlsvsqldsgtwtctvlqnqkkvefkidivvl
- Chain 'G':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4p9hL (L:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4p9hL (L:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnr