PDB entry 4p2c

View 4p2c on RCSB PDB site
Description: Complex of Shiga toxin 2e with a neutralizing single-domain antibody
Class: toxin
Keywords: Nanobody, Toxin, Complex, Lectin
Deposited on 2014-02-18, released 2014-07-30
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-01, with a file datestamp of 2014-09-26.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.19
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Shiga toxin 2e, subunit A
    Species: Escherichia coli [TaxId:562]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q7WUF4 (0-End)
      • engineered mutation (76)
      • engineered mutation (166)
      • variant (273)
      • variant (290)
    Domains in SCOPe 2.05: d4p2ca_
  • Chain 'B':
    Compound: Shiga toxin 2e, subunit B
    Species: Escherichia coli [TaxId:562]
    Gene: stxB2e, orf, stx2e B, stx2eB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cb_
  • Chain 'C':
    Compound: Shiga toxin 2e, subunit B
    Species: Escherichia coli [TaxId:562]
    Gene: stxB2e, orf, stx2e B, stx2eB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cc_
  • Chain 'D':
    Compound: Shiga toxin 2e, subunit B
    Species: Escherichia coli [TaxId:562]
    Gene: stxB2e, orf, stx2e B, stx2eB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cd_
  • Chain 'E':
    Compound: Shiga toxin 2e, subunit B
    Species: Escherichia coli [TaxId:562]
    Gene: stxB2e, orf, stx2e B, stx2eB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2ce_
  • Chain 'F':
    Compound: Shiga toxin 2e, subunit B
    Species: Escherichia coli [TaxId:562]
    Gene: stxB2e, orf, stx2e B, stx2eB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cf_
  • Chain 'G':
    Compound: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cg_
  • Chain 'H':
    Compound: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2ch_
  • Chain 'I':
    Compound: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2ci_
  • Chain 'J':
    Compound: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2cj_
  • Chain 'K':
    Compound: Nanobody 1, Anti-F4+ETEC bacteria VHH variable region
    Species: LAMA GLAMA [TaxId:9844]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4p2ck_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p2cA (A:)
qeftidfstqqsyvsslnsirtaistplehisqgatsvsvinhtppgsyisvgirgldvy
qerfdhlrliiernnlsvagfvntttntfyrfsdfahislpgvttismttdssyttpqrv
aalersgmqvsrhslvssylalmefsgntmtreasravlrfvtvtaqalrfrqiqrefrq
alsetapvytmtpedvdltlnwgrisnvlpeyrgeagvrvgrisfnnisailgtvaviln
chhqgarsvravneesqpecqitgdrpvikitntlwesntaaaflnrksqslyttge

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cA (A:)
qeftidfstqqsyvsslnsirtaistplehisqgatsvsvinhtppgsyisvgirgldvy
qerfdhlrliiernnlsvagfvntttntfyrfsdfahislpgvttismttdssyttpqrv
aalersgmqvsrhslvssylalmefsgntmtreasravlrfvtvtaqalrfrqiqrefrq
alsetapvytmtpedvdltlnwgrisnvlpeyrgeagvrvgrisfnnisailgtvaviln
checqitgdrpvikitntlwesntaaaflnrksqslyttg

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p2cB (B:)
adcakgkiefskynedntftvkvsgreywtnrwnlqpllqsaqltgmtvtiisntcssgs
gfaqvkfn

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p2cC (C:)
adcakgkiefskynedntftvkvsgreywtnrwnlqpllqsaqltgmtvtiisntcssgs
gfaqvkfn

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p2cD (D:)
adcakgkiefskynedntftvkvsgreywtnrwnlqpllqsaqltgmtvtiisntcssgs
gfaqvkfn

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p2cE (E:)
adcakgkiefskynedntftvkvsgreywtnrwnlqpllqsaqltgmtvtiisntcssgs
gfaqvkfn

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4p2cF (F:)
adcakgkiefskynedntftvkvsgreywtnrwnlqpllqsaqltgmtvtiisntcssgs
gfaqvkfn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4p2cG (G:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cG (G:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
s

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4p2cH (H:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cH (H:)
vqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyrd
svkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtvs

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4p2cI (I:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cI (I:)
vqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyrd
svkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtvs

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4p2cJ (J:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cJ (J:)
vqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyrd
svkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtvs
shhhhhh

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >4p2cK (K:)
qvqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyr
dsvkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4p2cK (K:)
vqlqesggglvqaggslrlscavsgsifrlstmgwyrqapgkqrefvasitsygdtnyrd
svkgrftisrdnakntvylqmnslkpedtavyycnanieagtyygpgrdywgqgtqvtvs