PDB entry 4ovz

View 4ovz on RCSB PDB site
Description: X-Ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-Like Proteases
Class: hydrolase/hydrolase inhibitor
Keywords: CoV, coronavirus, HCoV, human coronavirus, SARS, severe acute respiratory syndrome, MERS, Middle East respiratory syndrome, PLpro, protease inhibitor, complex, DUB, deubiquitinating enzyme, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2014-01-27, released 2014-04-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: papain-like proteinase
    Species: SARS coronavirus [TaxId:228330]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ovza1, d4ovza2
  • Chain 'B':
    Compound: papain-like proteinase
    Species: SARS coronavirus [TaxId:228330]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, P85, DMS, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ovzA (A:)
    mevktikvfttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlp
    sddtlrseafeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvlla
    lqqlevkfnapalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanle
    sakrvlnvvckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqes
    sfvmmsappaeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgp
    vtdvfyketsytttik
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ovzA (A:)
    fttvdntnlhtqlvdmsmtygqqfgptyldgadvtkikphvnhegktffvlpsddtlrse
    afeyyhtldesflgrymsalnhtkkwkfpqvggltsikwadnncylssvllalqqlevkf
    napalqeayyraragdaanfcalilaysnktvgelgdvretmthllqhanlesakrvlnv
    vckhcgqktttltgveavmymgtlsydnlktgvsipcvcgrdatqylvqqessfvmmsap
    paeyklqqgtflcaneytgnyqcghythitaketlyridgahltkmseykgpvtdvfyke
    tsytt
    

  • Chain 'B':
    No sequence available.