PDB entry 4omc
View 4omc on RCSB PDB site
Description: X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
Class: hydrolase/hydrolase inhibitor
Keywords: pro-protein convertase, serine protease, competitive inhibitor, protease-inhibitor complex, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2014-01-27, released
2014-04-09
The last revision prior to the SCOPe 2.03 freeze date was dated
2014-04-09, with a file datestamp of
2014-04-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.185
AEROSPACI score: 0.31
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4omca1, d4omca2 - Chain 'B':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
- Chain 'C':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4omcc1, d4omcc2 - Chain 'D':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.03: d4omcd1, d4omcd2 - Chain 'E':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
- Chain 'F':
Compound: Furin
Species: Homo sapiens [TaxId:9606]
Gene: FUR, FURIN, PACE, PCSK3
Database cross-references and differences (RAF-indexed):
- Chain 'H':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Chain 'J':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Chain 'K':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Chain 'N':
Compound: meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine
Database cross-references and differences (RAF-indexed):
- Heterogens: FMT, CA, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4omcA (A:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>4omcA (A:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygta
- Chain 'B':
No sequence available.
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4omcC (C:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>4omcC (C:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygta
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4omcD (D:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh
Sequence, based on observed residues (ATOM records): (download)
>4omcD (D:)
yqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnydp
gasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmldg
evtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsif
vwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqnek
qivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlnan
dwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevrk
tvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgfn
dwafmtthswdedpsgewvleientseannygtltkftlvlygta
- Chain 'E':
No sequence available.
- Chain 'F':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'I':
No sequence available.
- Chain 'J':
No sequence available.
- Chain 'K':
No sequence available.
- Chain 'L':
No sequence available.
- Chain 'N':
No sequence available.