PDB entry 4oiv
View 4oiv on RCSB PDB site
Description: Structural basis for small molecule NDB as a selective antagonist of FXR
Class: nuclear protein receptor
Keywords: bile acid sensor, nuclear, NUCLEAR PROTEIN RECEPTOR
Deposited on
2014-01-20, released
2015-03-25
The last revision prior to the SCOPe 2.05 freeze date was dated
2015-03-25, with a file datestamp of
2015-03-20.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bile acid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR1H4, BAR, FXR, HRR1, RIP14
Database cross-references and differences (RAF-indexed):
- Uniprot Q96RI1 (0-225)
- engineered mutation (188)
- engineered mutation (222)
Domains in SCOPe 2.05: d4oiva_ - Chain 'B':
Compound: Bile acid receptor
Species: Homo sapiens [TaxId:9606]
Gene: NR1H4, BAR, FXR, HRR1, RIP14
Database cross-references and differences (RAF-indexed):
- Uniprot Q96RI1 (0-225)
- engineered mutation (188)
- engineered mutation (222)
Domains in SCOPe 2.05: d4oivb_ - Heterogens: XX9, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4oivA (A:)
eltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlveftk
klpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyit
pmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihq
penpqhfaellgrltelrtfnhhhaemlmswrvndhkftplleeiw
Sequence, based on observed residues (ATOM records): (download)
>4oivA (A:)
eltpdqqtllhfimdsynksaeenfliltematnhvqvlveftkklpgfqtldhedqial
lkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyitpmfsfyksigelkmtq
eeyalltaivilspdrqyikdreaveklqeplldvlqklckihqpenpqhfaellgrlte
lrtfnhhhaemlmswrvndhkftplleeiw
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4oivB (B:)
eltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlveftk
klpgfqtldhedqiallkgsaveamflrsaeifnkklpsghsdlleerirnsgisdeyit
pmfsfyksigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihq
penpqhfaellgrltelrtfnhhhaemlmswrvndhkftplleeiw
Sequence, based on observed residues (ATOM records): (download)
>4oivB (B:)
eltpdqqtllhfimdsynkqrmpqeitnkilkeefsaeenfliltematnhvqvlveftk
klpgfqtldhedqiallkgsaveamflrsaeifnsdlleerirnsgisdeyitpmfsfyk
sigelkmtqeeyalltaivilspdrqyikdreaveklqeplldvlqklckihqpenpqhf
aellgrltelrtfnhhhaemlmswrvndhktplleeiw