PDB entry 4ohi

View 4ohi on RCSB PDB site
Description: LEOPARD Syndrome-Associated SHP2/Q510E mutant
Class: hydrolase
Keywords: sh2 domain, phosphatase domain, hydrolase
Deposited on 2014-01-17, released 2014-09-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-10-08, with a file datestamp of 2014-10-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.21
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 11
    Species: Homo sapiens [TaxId:9606]
    Gene: PTP2C, PTPN11, SHPTP2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q06124 (Start-527)
      • engineered mutation (509)
    Domains in SCOPe 2.05: d4ohia1, d4ohia2, d4ohia3
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ohiA (A:)
    mtsrrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntg
    dyydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgk
    eaeklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkyd
    vgggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelsklaett
    dkvkqgfweefetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdgdpnep
    vsdyinaniimpefetkcnnskpkksyiatqgclqntvndfwrmvfqensrvivmttkev
    ergkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqgntertvwqyhf
    rtwpdhgvpsdpggvldfleevhhkqesimdagpvvvhcsagigrtgtfividilidiir
    ekgvdcdidvpktiqmvrsqrsgmvqteaeyrfiymavqhyietlqrrlehhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ohiA (A:)
    srrwfhpnitgveaenllltrgvdgsflarpsksnpgdftlsvrrngavthikiqntgdy
    ydlyggekfatlaelvqyymehhgqlkekngdvielkyplncadptserwfhghlsgkea
    eklltekgkhgsflvresqshpgdfvlsvrtgddkgesndgkskvthvmircqelkydvg
    ggerfdsltdlvehykknpmvetlgtvlqlkqplnttrinaaeiesrvrelskvkqgfwe
    efetlqqqeckllysrkegqrqenknknryknilpfdhtrvvlhdsdyinaniimpekks
    yiatqgclqntvndfwrmvfqensrvivmttkevergkskcvkywpdeyalkeygvmrvr
    nvkesaahdytlrelklskvgqgntertvwqyhfrtwpdhgvpsdpggvldfleevhhkq
    esimdagpvvvhcsagigrtgtfividilidiirekgvdcdidvpktiqmvrsqrsgmvq
    teaeyrfiymavqhyietlqrr