PDB entry 4o6z

View 4o6z on RCSB PDB site
Description: Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum
Class: transferase
Keywords: alpha/beta protein, Transferase, methyltransferase activity, Cytosol
Deposited on 2013-12-24, released 2014-06-11
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-06-11, with a file datestamp of 2014-06-06.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: 0.228
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (32-37)
      • engineered mutation (329)
    Domains in SCOPe 2.04: d4o6za_
  • Chain 'B':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (35-37)
      • engineered mutation (329)
    Domains in SCOPe 2.04: d4o6zb_
  • Chain 'C':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (Start-479)
      • engineered mutation (329)
  • Chain 'D':
    Compound: serine hydroxymethyltransferase
    Species: PLASMODIUM FALCIPARUM [TaxId:36329]
    Gene: PFL1720w, SHMT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I566 (38-479)
      • expression tag (35-37)
      • engineered mutation (329)
  • Heterogens: PLP, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4o6zA (A:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4o6zA (A:)
hpftpgmfnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnky
segyphkryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvg
vkgkimgmhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfq
pkviicgytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvttt
thkilrgprsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefk
eytkqvllnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialn
kntipsdvdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvd
fkkglvnnpkidelkkevvqwaknlpfa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4o6zB (B:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdhpftpgmfnndplqkydkelfdllekek
nrqietinliasenltntavreclgdrisnkysegyphkryyggndyvdkieelcykral
eafnvseeewgvnvqplsgsaanvqalyalvgvkgkimgmhlcsgghlthgffdekkkvs
itsdlfesklykcnsegyvdmesvrnlalsfqpkviicgytsyprdidykgfreicdevn
aylfadishissfvacnllnnpftyadvvtttthkilrgprsaliffnkkrnpgidqkin
ssvfpsfqggphnnkiaavacqlkevntpefkeytkqvllnskalaecllkrnldlvtng
tdnhlivvdlrkynitgsklqetcnainialnkntipsdvdcvspsgirigtpalttrgc
kekdmefiadmllkailltdelqqkygkklvdfkkglvnnpkidelkkevvqwaknlpfa

    Sequence, based on observed residues (ATOM records): (download) 
    >4o6zB (B:)
tpgmfnndplqkydkelfdllekeknrqietinliasenltntavreclgdrisnkyseg
yphkryyggndyvdkieelcykraleafnvseeewgvnvqplsgsaanvqalyalvgvkg
kimgmhlcsgghlthgffdekkkvsitsdlfesklykcnsegyvdmesvrnlalsfqpkv
iicgytsyprdidykgfreicdevnaylfadishissfvacnllnnpftyadvvtttthk
ilrgprsaliffnkkrnpgidqkinssvfpsfqggphnnkiaavacqlkevntpefkeyt
kqvllnskalaecllkrnldlvtngtdnhlivvdlrkynitgsklqetcnainialnknt
ipsdvdcvspsgirigtpalttrgckekdmefiadmllkailltdelqqkygkklvdfkk
glvnnpkidelkkevvqwaknlpfa

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.