PDB entry 4nyj

View 4nyj on RCSB PDB site
Description: Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange
Class: Signaling protein
Keywords: GTPase, signaling transduction, Raf, RalGDS, PI3K, cytosol, Signaling protein
Deposited on 2013-12-10, released 2014-03-12
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-03-19, with a file datestamp of 2014-03-14.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.157
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'Q':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (0-165)
      • engineered mutation (63)
    Domains in SCOPe 2.06: d4nyjq_
  • Chain 'R':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nyjr_
  • Chain 'S':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4nyjs_
  • Heterogens: MG, GNP, 2PZ, HOH

PDB Chain Sequences:

  • Chain 'Q':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4nyjQ (Q:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4nyjR (R:)
    mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
    qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
    aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh
    

  • Chain 'S':
    Sequence, based on SEQRES records: (download)
    >4nyjS (S:)
    qmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfvr
    tflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpv
    qlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiard
    ngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselv
    gsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqel
    nnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinpp
    cvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrves
    dikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnp
    r
    

    Sequence, based on observed residues (ATOM records): (download)
    >4nyjS (S:)
    qmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltty
    rsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvln
    vcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkianitfqssp
    ptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeins
    pnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsam
    nsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnil
    kteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmg
    nsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr