PDB entry 4nr8
View 4nr8 on RCSB PDB site
Description: Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
Class: transcription/inhibitor
Keywords: Structural Genomics Consortium, SGC, chemical tool, small molecule inhibitor, transcription, TRANSCRIPTION-INHIBITOR complex
Deposited on
2013-11-26, released
2013-12-25
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-12-25, with a file datestamp of
2013-12-20.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: 0.215
AEROSPACI score: 0.46
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Bromodomain-containing protein 4
Species: Homo sapiens [TaxId:9606]
Gene: BRD4, HUNK1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4nr8a1, d4nr8a2 - Heterogens: K, 2LL, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4nr8A (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelptee
Sequence, based on observed residues (ATOM records): (download)
>4nr8A (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpt