PDB entry 4nr4

View 4nr4 on RCSB PDB site
Description: Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand
Class: transcription/inhibitor
Keywords: Structural Genomics Consortium, SGC, chemical tool, small molecule inhibitor, transcription, TRANSCRIPTION-INHIBITOR complex
Deposited on 2013-11-26, released 2013-12-18
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-12-18, with a file datestamp of 2013-12-13.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.156
AEROSPACI score: 0.51 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: creb-binding protein
    Species: Homo sapiens [TaxId:9606]
    Gene: CBP, CREBBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nr4a_
  • Chain 'B':
    Compound: creb-binding protein
    Species: Homo sapiens [TaxId:9606]
    Gene: CBP, CREBBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4nr4b_
  • Heterogens: 2LK, EDO, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4nr4A (A:)
smrkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlsti
krkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >4nr4A (A:)
fkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkldt
gqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4nr4B (B:)
smrkkifkpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlsti
krkldtgqyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg

    Sequence, based on observed residues (ATOM records): (download) 
    >4nr4B (B:)
kpeelrqalmptlealyrqdpeslpfrqpvdpqllgipdyfdivknpmdlstikrkldtg
qyqepwqyvddvwlmfnnawlynrktsrvykfcsklaevfeqeidpvmqslg