PDB entry 4ncs

View 4ncs on RCSB PDB site
Description: Human sialidase 2 in complex with 2,3-difluorosialic acid (covalent intermediate)
Class: hydrolase
Keywords: Sialidase, Human neuraminidase, fluoro-sialic acid, Hydrolase
Deposited on 2013-10-25, released 2013-12-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-04-02, with a file datestamp of 2014-03-28.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.164
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sialidase-2
    Species: Homo sapiens [TaxId:9606]
    Gene: NEU2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y3R4
      • engineered mutation (169)
    Domains in SCOPe 2.06: d4ncsa_
  • Heterogens: FSR, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4ncsA (A:)
    gsmaslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkaehaelivlrrgd
    ydapthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtr
    anvtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpa
    yayrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnars
    hlrarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythp
    thswqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeand
    yeeivflmftlkqafpaeylpq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ncsA (A:)
    aslpvlqkesvfqsgahayripallylpgqqsllafaeqraaelivlrrgdydapthqvq
    wqaqevvaqarldghrsmnpcplydaqtgtlflffiaipganvtrlcqvtstdhgrtwss
    prdltdaaigpayrewstfavgpghclqlndrarslvvpayayrklhpiqrpipsafcfl
    shdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrarvqaqstndgldfqesqlv
    kklvepppqgcqgsvisfpspraqwllythpthswqradlgaylnprppapeawsepvll
    akgscaysdlqsmgtgpdgsplfgclyeandyeeivflmftlkqafpaey