PDB entry 4m2x

View 4m2x on RCSB PDB site
Description: Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Structural Genomics, TB Structural Genomics Consortium, TBSGC, reductase, NADPH binding, Hydride transfer, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2013-08-05, released 2014-11-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 2.26 Å
R-factor: 0.197
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: folA, dfrA, Rv2763c, MT2833, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m2xa_
  • Chain 'C':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: folA, dfrA, Rv2763c, MT2833, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m2xc_
  • Chain 'E':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: folA, dfrA, Rv2763c, MT2833, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m2xe_
  • Chain 'G':
    Compound: dihydrofolate reductase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: folA, dfrA, Rv2763c, MT2833, MTV002.28c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4m2xg_
  • Heterogens: NDP, TMQ, ACT, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4m2xA (A:)
gshmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrpl
pgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdi
glpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4m2xA (A:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4m2xC (C:)
gshmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrpl
pgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdi
glpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4m2xC (C:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4m2xE (E:)
gshmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrpl
pgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdi
glpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4m2xE (E:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4m2xG (G:)
gshmvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrpl
pgrrnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdi
glpreagdalapvldetwrgetgewrfsrsglryrlysyhrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4m2xG (G:)
mvgliwaqatsgvigrggdipwrlpedqahfreitmghtivmgrrtwdslpakvrplpgr
rnvvlsrqadfmasgaevvgsleealtspetwvigggqvyalalpyatrcevtevdiglp
reagdalapvldetwrgetgewrfsrsglryrlysyhrs