PDB entry 4lyj
View 4lyj on RCSB PDB site
Description: Crystal Structure of small molecule vinylsulfonamide 9 covalently bound to K-Ras G12C, alternative space group
Class: signaling protein/inhibitor
Keywords: GTPase, GDP bound, small molecule inhibitor, covalent binder, SIGNALING PROTEIN-INHIBITOR complex
Deposited on
2013-07-31, released
2013-11-27
The last revision prior to the SCOPe 2.03 freeze date was dated
2013-12-18, with a file datestamp of
2013-12-13.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: 0.182
AEROSPACI score: 0.41
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS isoform 2B, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116
- variant (12)
- engineeered mutation (51)
- engineeered mutation (80)
- engineeered mutation (118)
- see remark 999 (151)
- see remark 999 (153)
- see remark 999 (165-167)
Domains in SCOPe 2.03: d4lyja_ - Heterogens: MG, 21F, GDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4lyjA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>4lyjA (A:)
teyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtagq
eeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk