PDB entry 4lk3

View 4lk3 on RCSB PDB site
Description: Crystal structure of Human UDP-xylose synthase R236A substitution
Class: lyase
Keywords: short-chain dehydrogenase/reductase, decarboxylase, lyase, membrane, rossmann fold
Deposited on 2013-07-05, released 2013-08-07
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-11-12, with a file datestamp of 2014-11-07.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: 0.2
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3a_
  • Chain 'B':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3b_
  • Chain 'C':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3c_
  • Chain 'D':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3d_
  • Chain 'E':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3e_
  • Chain 'F':
    Compound: UDP-glucuronic acid decarboxylase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: UNQ2538/PRO6079, UXS, UXS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8NBZ7
      • engineered mutation (151)
    Domains in SCOPe 2.05: d4lk3f_
  • Heterogens: NAD, UDP, UGA, SO4, POP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lk3A (A:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3A (A:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspasynpiktlktntigtlnmlglakrvgarlllastsevyegkava
etmcyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgepltvyqtrafqyv
sdlvnglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseiqfrkpdikkaklml
gwepvvpleeglnkaihyfrkeleyqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lk3B (B:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3B (B:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspaspmynpiktlktntigtlnmlglakrvgarlllastsevyegka
vaetmcyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgepltvygsgsqt
rafqyvsdlvnglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseiqflrkpdi
kkaklmlgwepvvpleeglnkaihyfrkeleyqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4lk3C (C:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3C (C:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspasynpiktlktntigtlnmlglakrvgarlllastsevyegkava
etmcyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgepltvygsgsqtra
fqyvsdlvnglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseiqflkpdikka
klmlgwepvvpleeglnkaihyfrkeleyqa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4lk3D (D:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3D (D:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspaspynpiktlktntigtlnmlglakrvgarlllastsevyegkav
aetmcyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgepltvygsgsqtr
afqyvsdlvnglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseiqflrkpdik
kaklmlgwepvvpleeglnkaihyfrkeleyqa

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4lk3E (E:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3E (E:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspnpiktlktntigtlnmlglakrvgarlllastsevyegkavaetm
cyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgepltvygsgsqtrafqy
vsdlvnglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseiqflrkpdikkakl
mlgwepvvpleeglnkaihyfrkeleyqa

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4lk3F (F:)
ekdrkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhd
vveplyievdqiyhlaspasppnymynpiktlktntigtlnmlglakrvgarlllastse
vygdpevhpqsedywghvnpigpracydegkavaetmcyaymkqegvevrvarifntfgp
rmhmndgrvvsnfilqalqgepltvygsgsqtrafqyvsdlvnglvalmnsnvsspvnlg
npeehtilefaqliknlvgsgseiqflseaqddpqkrkpdikkaklmlgwepvvpleegl
nkaihyfrkeleyqannqyipkpkparikkgrtrhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4lk3F (F:)
rkrilitggagfvgshltdklmmdghevtvvdnfftgrkrnvehwighenfelinhdvve
plyievdqiyhlaspynpiktlktntigtlnmlglakrvgarlllastsevyegkavaet
mcyaymkqegvevrvarifntfgprmhmndgrvvsnfilqalqgeplsqtrafqyvsdlv
nglvalmnsnvsspvnlgnpeehtilefaqliknlvgsgseirkpdikkaklmlgwepvv
pleeglnkaihyfrkeleyqa