PDB entry 4lh2

View 4lh2 on RCSB PDB site
Description: Structure of mouse 1-Pyrroline-5-Carboxylate Dehydrogenase (ALDH4A1) complexed with succinate
Class: oxidoreductase
Keywords: Proline catabolism, Substrate recognition, Rossmann Fold, OXIDOREDUCTASE
Deposited on 2013-06-30, released 2013-08-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-10-09, with a file datestamp of 2013-10-04.
Experiment type: XRAY
Resolution: 1.67 Å
R-factor: 0.165
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: ADLH4a1, Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (Start-562)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d4lh2a_
  • Chain 'B':
    Compound: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Species: Mus musculus [TaxId:10090]
    Gene: ADLH4a1, Aldh4a1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8CHT0 (21-562)
      • expression tag (19-20)
      • conflict (32)
      • conflict (60)
      • conflict (467)
    Domains in SCOPe 2.08: d4lh2b1, d4lh2b2
  • Heterogens: 1PE, SIN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4lh2A (A:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >4lh2A (A:)
lkvanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdiqyqlspfnhah
kvakfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgprraevlaktmv
gqgktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyrglegfvaaisp
fnftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppniiqfvpadgptf
gdtvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggknfhfvhssadv
dsvvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvgdpaedfgtffs
avidakafarikkwleharsspslsilaggqcnesvgyyvepciieskdpqepimkeeif
gpvltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlrnaagnfyindk
stgsvvgqqpfggarasgtndkpggphyilrwtspqvikethkplgdwrysymq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4lh2B (B:)
mgsshhhhhhssglvprgshmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgq
teaipcvvgdeevwtsdiqyqlspfnhahkvakfcyadkallnraidaalaarkewdlkp
madraqvflkaadmlsgprraevlaktmvgqgktviqaeidaaaelidffrfnakfavel
egeqpisvppstnhtvyrglegfvaaispfnftaiggnlagapalmgnvvlwkpsdtaml
asyavyrilreaglppniiqfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaq
nldrfrtfprlagecggknfhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpksl
wpqikgrlleehsrikvgdpaedfgtffsavidakafarikkwleharsspslsilaggq
cnesvgyyvepciieskdpqepimkeeifgpvltvyvypddkyretlklvdsttsygltg
avfaqdkaivqeatrmlrnaagnfyindkstgsvvgqqpfggarasgtndkpggphyilr
wtspqvikethkplgdwrysymq

    Sequence, based on observed residues (ATOM records): (download) 
    >4lh2B (B:)
hmlrwkhtsslkvanepilafsqgsperdalqkalkdlkgqteaipcvvgdeevwtsdiq
yqlspfnhahkvakfcyadkallnraidaalaarkewdlkpmadraqvflkaadmlsgpr
raevlaktmvgqgktviqaeidaaaelidffrfnakfavelegeqpisvppstnhtvyrg
legfvaaispfnftaiggnlagapalmgnvvlwkpsdtamlasyavyrilreaglppnii
qfvpadgptfgdtvtssehlcginftgsvptfkhlwrqvaqnldrfrtfprlagecggkn
fhfvhssadvdsvvsgtlrsafeyggqkcsacsrlyvpkslwpqikgrlleehsrikvgd
paedfgtffsavidakafarikkwleharsspslsilaggqcnesvgyyvepciieskdp
qepimkeeifgpvltvyvypddkyretlklvdsttsygltgavfaqdkaivqeatrmlrn
aagnfyindkstgsvvgqqpfggarasgtndkpggphyilrwtspqvikethkplgdwry
symq