PDB entry 4lgh

View 4lgh on RCSB PDB site
Description: Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase
Class: transferase/transferase inhibitor
Keywords: Kinase Domain, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2013-06-27, released 2013-08-07
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-08-07, with a file datestamp of 2013-08-02.
Experiment type: XRAY
Resolution: 2.84 Å
R-factor: 0.216
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (0-276)
      • engineered mutation (81)
    Domains in SCOPe 2.03: d4lgha_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00523 (Start-276)
      • engineered mutation (81)
    Domains in SCOPe 2.03: d4lghb_
  • Heterogens: 0JN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4lghA (A:)
    kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
    lrheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgmay
    vermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaaly
    grftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmc
    qcwrkdpeerptfeylqafledyftstepqyqpgenl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4lghA (A:)
    kdaweipreslrlevklgqggevwmgtwngtrvaiktleaqvmkklrheklvqlyavvse
    epiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlraan
    ilvgenlvckvadfpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnre
    vldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpg
    enl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4lghB (B:)
    kdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkk
    lrheklvqlyavvseepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgmay
    vermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpikwtapeaaly
    grftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmc
    qcwrkdpeerptfeylqafledyftstepqyqpgenl
    

    Sequence, based on observed residues (ATOM records): (download)
    >4lghB (B:)
    aweipreslrlevklgqcfgevwmgtwngttrvaiktlkpeaqvmkklrheklvqlyavv
    seepiyivgeymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermnyvhrdlra
    anilvgenlvckvadfglpikwtapeaalygrftiksdvwsfgilltelttkgrvpypgm
    vnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafledyftstepq
    yqpgenl