PDB entry 4kz0

View 4kz0 on RCSB PDB site
Description: Structure of PI3K gamma with Imidazopyridine inhibitors
Class: Transferase/Transferase Inhibitor
Keywords: Lipid Kinase, Transferase-Transferase Inhibitor complex
Deposited on 2013-05-29, released 2013-07-17
The last revision prior to the SCOPe 2.06 freeze date was dated 2013-08-28, with a file datestamp of 2013-08-23.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: 0.209
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed):
    • Uniprot P48736 (1-End)
      • engineered mutation (316)
    Domains in SCOPe 2.06: d4kz0a1, d4kz0a2, d4kz0a3, d4kz0a4
  • Heterogens: 1UJ, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kz0A (A:)
mseesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwv
tskplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdip
esqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkee
wplvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvf
veaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapals
skasaespsseskgkvrllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadkl
tsatnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatd
plnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsal
dvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfll
krglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqvieml
qkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekck
vmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldl
cllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfq
aaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginker
vpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpql
tskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa
hhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4kz0A (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmqdfvlrvcgrd
eylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeevslwdcdrkfrvkirg
idipvltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqi
ycvrllyyvnlllidhrfllrrgeyvlhmwqifnadkltsatnpdkensmsisilldnem
pnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivakt
yqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqav
kfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgta
mlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpy
dpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqi
lrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevl
nhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfgh
ilgnrvpfvltpdflfvmgtsktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgm
pqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvl