PDB entry 4kxz
View 4kxz on RCSB PDB site
Description: crystal structure of tgfb2 in complex with GC2008.
Class: immune system
Keywords: Cysteine knot, Fab, Various growth functions (TGF-beta), TGF-beta antagonist (GC2008), TGF-beta receptors, immune system
Deposited on
2013-05-28, released
2014-09-24
The last revision prior to the SCOPe 2.08 freeze date was dated
2014-12-03, with a file datestamp of
2014-11-28.
Experiment type: XRAY
Resolution: 2.83 Å
R-factor: 0.183
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transforming growth factor beta-2
Species: Homo sapiens [TaxId:9606]
Gene: TGFB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxza_ - Chain 'B':
Compound: Transforming growth factor beta-2
Species: Homo sapiens [TaxId:9606]
Gene: TGFB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzb_ - Chain 'D':
Compound: Transforming growth factor beta-2
Species: Homo sapiens [TaxId:9606]
Gene: TGFB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzd_ - Chain 'E':
Compound: Transforming growth factor beta-2
Species: Homo sapiens [TaxId:9606]
Gene: TGFB2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxze_ - Chain 'H':
Compound: GC1008 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'I':
Compound: GC1008 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzi1, d4kxzi2 - Chain 'J':
Compound: GC1008 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: GC1008 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzl1, d4kxzl2 - Chain 'M':
Compound: GC1008 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzm1, d4kxzm2 - Chain 'N':
Compound: GC1008 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'P':
Compound: GC1008 Light Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4kxzp1, d4kxzp2 - Chain 'Q':
Compound: GC1008 Heavy Chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: MES, PE5, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4kxzA (A:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4kxzB (B:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>4kxzD (D:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>4kxzE (E:)
aldaaycfrnvqdncclrplyidfkrdlgwkwihepkgynanfcagacpylwssdtqhsr
vlslyntinpeasaspccvsqdlepltilyyigktpkieqlsnmivksckcs
- Chain 'H':
No sequence available.
- Chain 'I':
Sequence, based on SEQRES records: (download)
>4kxzI (I:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4kxzI (I:)
tvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgipd
rfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrg
- Chain 'J':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4kxzL (L:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4kxzL (L:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrg
- Chain 'M':
Sequence, based on SEQRES records: (download)
>4kxzM (M:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4kxzM (M:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrg
- Chain 'N':
No sequence available.
- Chain 'P':
Sequence, based on SEQRES records: (download)
>4kxzP (P:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4kxzP (P:)
etvltqspgtlslspgeratlscrasqslgssylawyqqkpgqaprlliygassrapgip
drfsgsgsgtdftltisrlepedfavyycqqyadspitfgqgtrleikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrg
- Chain 'Q':
No sequence available.