PDB entry 4kw6

View 4kw6 on RCSB PDB site
Description: Crystal structure of Peroxiredoxin-1 (C-terminal truncation mutant) from the human hookworm Ancylostoma ceylanicum bound to conoidin A
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: 2-cys peroxiredoxin, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2013-05-23, released 2013-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-09-11, with a file datestamp of 2013-09-06.
Experiment type: XRAY
Resolution: 3 Å
R-factor: 0.187
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxiredoxin-1
    Species: Ancylostoma ceylanicum [TaxId:53326]
    Database cross-references and differences (RAF-indexed):
    • Uniprot J7HJM3 (8-178)
      • expression tag (7)
    Domains in SCOPe 2.08: d4kw6a1, d4kw6a2
  • Chain 'B':
    Compound: Peroxiredoxin-1
    Species: Ancylostoma ceylanicum [TaxId:53326]
    Database cross-references and differences (RAF-indexed):
    • Uniprot J7HJM3 (8-End)
      • expression tag (7)
    Domains in SCOPe 2.08: d4kw6b1, d4kw6b2
  • Chain 'C':
    Compound: Peroxiredoxin-1
    Species: Ancylostoma ceylanicum [TaxId:53326]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kw6c_
  • Chain 'D':
    Compound: Peroxiredoxin-1
    Species: Ancylostoma ceylanicum [TaxId:53326]
    Database cross-references and differences (RAF-indexed):
    • Uniprot J7HJM3 (8-178)
      • expression tag (7)
    Domains in SCOPe 2.08: d4kw6d1, d4kw6d2
  • Chain 'E':
    Compound: Peroxiredoxin-1
    Species: Ancylostoma ceylanicum [TaxId:53326]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4kw6e_
  • Heterogens: QDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4kw6A (A:)
mhhhhhhhmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpte
iiafsdrfpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakd
ygvlkddegiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

    Sequence, based on observed residues (ATOM records): (download) 
    >4kw6A (A:)
hmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpteiiafsdr
fpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakdygvlkdd
egiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4kw6B (B:)
mhhhhhhhmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpte
iiafsdrfpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakd
ygvlkddegiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

    Sequence, based on observed residues (ATOM records): (download) 
    >4kw6B (B:)
hmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpteiiafsdr
fpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakdygvlkdd
egiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevc

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4kw6C (C:)
mhhhhhhhmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpte
iiafsdrfpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakd
ygvlkddegiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

    Sequence, based on observed residues (ATOM records): (download) 
    >4kw6C (C:)
mskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpteiiafsdrf
pefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakdygvlkdde
giayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevc

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4kw6D (D:)
mhhhhhhhmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpte
iiafsdrfpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakd
ygvlkddegiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

    Sequence, based on observed residues (ATOM records): (download) 
    >4kw6D (D:)
hmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpteiiafsdr
fpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakdygvlkdd
egiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4kw6E (E:)
mhhhhhhhmskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpte
iiafsdrfpefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakd
ygvlkddegiayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp

    Sequence, based on observed residues (ATOM records): (download) 
    >4kw6E (E:)
mskafigkpapdfatkavfdgdfvdvklsdykgkyvvlffypldftfvcpteiiafsdrf
pefknlnvavlacstdsvfshlawintprkhgglgdmkipvladtnhqiakdygvlkdde
giayrglfiidpkgilrqitindlpvgrsvdetlrlvqafqytdkhgevcp