PDB entry 4ktt

View 4ktt on RCSB PDB site
Description: Structural insights of MAT enzymes: MATa2b complexed with SAM
Class: transferase
Keywords: SAMe Synthesis, TRANSFERASE
Deposited on 2013-05-21, released 2014-07-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-09-24, with a file datestamp of 2014-09-19.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.221
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ktta1, d4ktta2, d4ktta3
  • Chain 'B':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kttb1, d4kttb2, d4kttb3
  • Chain 'C':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kttc1, d4kttc2, d4kttc3
  • Chain 'D':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kttd1, d4kttd2, d4kttd3
  • Chain 'E':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ktte_
  • Chain 'F':
    Compound: methionine adenosyltransferase 2 subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2B, TGR, MSTP045, Nbla02999, UNQ2435/PRO4995
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4kttf_
  • Heterogens: EDO, SAM, PO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4kttA (A:)
    smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
    aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
    gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
    sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
    tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
    wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
    ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttA (A:)
    egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
    aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspqglmfgyatdeteecmplt
    ivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdeev
    cldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtygg
    wgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaishplsisifhy
    gtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4kttB (B:)
    smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
    aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
    gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
    sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
    tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
    wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
    ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttB (B:)
    eegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageits
    raavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigag
    dqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrg
    avlpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfvig
    gpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrr
    vlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqr
    taayghfgrdsfpwevpkklky
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4kttC (C:)
    smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
    aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
    gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
    sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
    tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
    wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
    ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttC (C:)
    egtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsr
    aavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdqglmfgyatdeteecmpl
    tivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgavlpirvhtivisvqhdee
    vcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggpqgdagltgrkiivdtyg
    gwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvlvqvsyaihplsisifhy
    gtsqkserelleivkknfdlrpgvivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4kttD (D:)
    smngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetv
    aktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaq
    gvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpd
    sktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylded
    tiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaar
    wvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgv
    ivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttD (D:)
    gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
    avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
    glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
    lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
    qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
    vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
    ayghfgrdsfpwevpkklky
    

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >4kttE (E:)
    gshmmpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkf
    eqvnlldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaav
    gafliyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilyg
    evekleesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgt
    fhwsgneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigq
    rtpfrigikeslwpflidkrwrqtvfh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttE (E:)
    pnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdfq
    phvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaavgafliyissdyvfdgtnpp
    yreedipaplnlygktkldgekavlennlgaavlripilygevekleesavtvmfdkvqf
    snksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacaia
    dafnlpsshlrpitdspvlqrprnaqldcskletlgigqrtpfrigikeslwpflidkrw
    rqtvfh
    

  • Chain 'F':
    Sequence, based on SEQRES records: (download)
    >4kttF (F:)
    gshmmpempedmeqeevnipnrrvlvtgatgllgravhkefqqnnwhavgcgfrrarpkf
    eqvnlldsnavhhiihdfqphvivhcaaerrpdvvenqpdaasqlnvdasgnlakeaaav
    gafliyissdyvfdgtnppyreedipaplnlygktkldgekavlennlgaavlripilyg
    evekleesavtvmfdkvqfsnksanmdhwqqrfpthvkdvatvcrqlaekrmldpsikgt
    fhwsgneqmtkyemacaiadafnlpsshlrpitdspvlgaqrprnaqldcskletlgigq
    rtpfrigikeslwpflidkrwrqtvfh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4kttF (F:)
    vlvtgatgllgravhkefqqnnwhavgcgfrrarpkfeqvnlldsnavhhiihdfqphvi
    vhcaaerrpdvvdasgnlakeaaavgafliyissdyvfdgtnppyreedipaplnlygkt
    kldgekavlennavlripilygevekleesavtvmfdkvqfsnksanmdhwqqrfpthvk
    dvatvcrqlaekrmldpsikgtfhwsgneqmtkyemacaiadafnlpsshlrpiqrprna
    qldcskletlggqrtpfrigikeslwpflidkrwrqtvfh