PDB entry 4krp
View 4krp on RCSB PDB site
Description: Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
Class: transferase/immune system
Keywords: cell surface receptor, glycoprotein, nanobody, VHH domain, Camelid VH domain, antibody, antigen, antibody complex, TRANSFERASE-IMMUNE SYSTEM complex
Deposited on
2013-05-16, released
2013-08-28
The last revision prior to the SCOPe 2.04 freeze date was dated
2013-08-28, with a file datestamp of
2013-08-23.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.217
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Epidermal growth factor receptor
Species: Homo sapiens [TaxId:9606]
Gene: EGFR, ERBB, ERBB1, HER1
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: Nanobody/VHH domain 9G8
Species: LAMA GLAMA [TaxId:9844]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4krpb_ - Chain 'C':
Compound: Cetuximab light chain
Species: Mus musculus, Homo sapiens [TaxId:10090, 9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4krpc1, d4krpc2 - Chain 'D':
Compound: Cetuximab heavy chain
Species: Mus musculus, Homo sapiens [TaxId:10090, 9606]
Database cross-references and differences (RAF-indexed):
- Heterogens: NAG, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4krpB (B:)
evqlvesggglvqaggslrlscaasgrtfssyamgwfrqapgkerefvvainwssgstyy
adsvkgrftisrdnakntmylqmnslkpedtavyycaagyqinsgnynfkdyeydywgqg
tqvtvssalehhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4krpB (B:)
evqlvesgggllscaasgrtfssyamgwfrqapgkerefvvainwssgstyyadsvkgrf
tisrdnakntmylqmnslkpedtavyycaagyqinsgnynfkdyeydywgqgtqvt
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>4krpC (C:)
dilltqspvilsvspgervsfscrasqsigtnihwyqqrtngsprllikyasesisgips
rfsgsgsgtdftlsinsvesediadyycqqnnnwpttfgagtklelkrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr
- Chain 'D':
No sequence available.